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2-[[(4-Methoxy-3-Methyl-2-Pyridinyl)methyl]thio]-6-(1H-Pyrrol-1-yl)-1H-Benzimidazole
Basic information
Product Name: 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole
Synonyms: 2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole;5-(1H-pyrrol-1-yl)-2-[(4-methoxy-3-methyl-2-pyridyl)-methylthio]-1-hydro-benzimidazole;Ilaprazole Impurity 1 (Desoxy Ilaprazole);1H-Benzimidazole, 2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-;2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]thio]-6-(1H-pyrrol-1-yl)-1H-benzimidazole ISO 9001：2015 REACH;2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfanyl]5-(1H-pyrrol-1-yl) 1H benzimidazole;Desoxy Ilaprazole;2-(((4-Methoxy-3-methylpyridin-2-yl)methyl)thio)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole
CAS: 172152-35-1
MF: C19H18N4OS
MW: 350.44
Chemical Properties
Boiling Point: 590.4±60.0°C（Predicted）
Density: 1.30±0.1 g/cm3(Predicted)
Pka: 9.26±0.10(Predicted)
InChI: InChI=1S/C19H18N4OS/c1-13-17(20-8-7-18(13)24-2)12-25-19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
InChIKey: TZNQIYXOVOTIKQ-UHFFFAOYSA-N
SMILES: C1(SCC2=NC=CC(OC)=C2C)NC2=CC(N3C=CC=C3)=CC=C2N=1
Product Introduction
The following is an introduction to the nature, use, preparation and safety information of Ome-PyBOP:
Quality:
1. It is an organic solid with white or off-white color.
2. Stable at room temperature, soluble in common organic solvents, such as dimethyl sulfoxide (DMSO), dichloromethane and ethyl diacetate.
Use:
1. It is an important chemical intermediate, which is often used in acylation reaction and condensation reaction in organic synthesis.
2. It can be used to synthesize peptides and peptide compounds, with high efficiency, high selectivity and good reaction conditions.
Method:
Generally, the following steps are performed: 2-amino-6-(1H-pyrrole-1-yl)-1H-benzimidazole is reacted with 4-methoxy-3-methyl-2-pyridine methanol to generate an intermediate; Then, it reacts with tetrahydrofuran and carbon disulfide to form Ome-PyBOP; Pure products are obtained by crystallization purification.
Safety Information:
1. There is no special safety risk in general operation, but basic laboratory safety operation specifications should still be observed.
2. When operating, wear appropriate protective gloves and eye protection equipment, and ensure that the operation is carried out in a well-ventilated laboratory.