1187595-85-2, also known as 2-[1-(ethylsulfonyl)-3-azetidinyl]acetonitrile, is an important organic synthetic intermediate primarily used in the synthesis of Baricitinib. Baricitinib is a Janus kinase (JAK) inhibitor drug used for the treatment of inflammatory diseases such as rheumatoid arthritis. This compound has the molecular formula C7H10N2O2S and a molecular weight of 186.23. It exists in a solid state, with a color ranging from grayish-white to light yellow, a melting point of 67-69°C, a boiling point of 360.8±52.0 °C (predicted), and a density of 1.33±0.1 g/cm3 (predicted). Storage conditions require sealing and storage at room temperature, and it is slightly soluble in DMSO and methanol. The acid dissociation constant (pKa) is -8.49±0.20 (predicted). In the pharmaceutical manufacturing field, 1187595-85-2 is particularly significant due to its application in the synthesis of Baricitinib, playing a crucial role in the development of effective treatment plans.
