3-Fluoro-4-broMoaniline(CAS NO.:656-65-5)
Basic information
Product Name: 3-Fluoro-4-broMoaniline
Synonyms:
CAS: 656-65-5
MF: C6H5BrFN
MW: 190.01
Chemical Properties
Boiling Point: 65-68 °C (lit.)
Density: 0.982 g/mL at 25 °C (lit.)
storage temp: Keep in dark place,Sealed in dry,Room Temperature
Solubility: Acetonitrile, Methanol
Form: Crystalline Powder
Pka: 2.88±0.10(Predicted)
Color: Yellow to tan
InChI: NA
InChIKey: YTMVYYAKOPIJCZ-UHFFFAOYSA-N
SMILES: NA
product description
Here's what it does:
Pharmaceutical synthesis: 4-bromo-3-fluoroaniline is an important raw material for the synthesis of a variety of medicines. For example, it is a key intermediate of the anti-infective drug tedizolid. In the synthesis of tedizolid, 4-bromo-3-fluoroaniline is transformed into a target product through a series of reaction steps such as addition, cyclization, and ester hydrolysis.
Raw materials for organic synthesis: 4-bromo-3-fluoroaniline is also a widely used raw material for organic synthesis, which can be used for the preparation of corresponding indole compounds
, and the synthesis of several laterally difluorinated 4,4-dialkyl and 4,4-alkoxyalkyl terphenyls.
Synthesis of drug molecules: 4-bromo-3-fluoroaniline can be used in the industrial production of the drug molecule tedizolid phosphate, which is a protein biosynthesis inhibitor, with the help of the chemical properties of its bromine atom and amino group.
Antimicrobial drugs: 4-bromo-3-fluoroaniline is an intermediate in the preparation of the drug molecule tedizolid, which is a second-generation oxazolidinone antibacterial drug, which was approved by the U.S. Food and Drug Administration (FDA) in June 2014 for the treatment of acute bacterial skin and skin structure infections in adults.
Chemical reactivity: The chemical structure of 4-bromo-3-fluoroaniline contains bromine atoms and amino groups, showing high chemical reactivity. For example, the amino group on the benzene ring has significant nucleophilicity, and can undergo nucleophilic substitution reaction with common electrophiles to obtain corresponding N-alkylated aniline derivatives.
Reduction reaction: 4-bromo-3-fluoroaniline can be reduced under suitable conditions to produce aminobenzene or other derivatives.