3-Thiophenemalonic acid(CAS NO.:21080-92-2 Advanced Pharmaceutical Intermediates)
Basic information
Product Name: 3-Thiophenemalonic acid
Synonyms:
CAS: 21080-92-2
MF: C7H6O4S
MW: 186.19
Chemical Properties
Melting point: 139 °C (dec.) (lit.)
Boiling point: 290.67°C (rough estimate)
Density: 1.5439 (rough estimate)
Refractive Index: 1.5500 (estimate)
Pka: 2.73±0.10(Predicted)
Form: powder to crystal
Color: White to Orange to Green
BRN: 6503620
CAS DataBase Reference: 21080-92-2(CAS DataBase Reference)
EPA Substance Registry System: Propanedioic acid, 3-thienyl- (21080-92-2)
Product Introduction
The following is an introduction to the properties, uses, preparation methods and safety information of 3-thiophenylmalonic acid:
Quality:
1. Appearance: 3-thiophenylmalonic acid is a colorless crystalline solid.
3. Solubility: It has a certain solubility in water and organic solvents (such as ethanol, acetone).
4. Chemical properties: 3-thiophenylmalonic acid is an acidic substance that can react with alkali to form salts.
Use:
1. Chemical synthesis: 3-thiophenylmalonic acid can be used as a starting material in organic synthesis for the synthesis of various organic acids, esters, amides and other compounds.
2. Fluorescent probe: It has fluorescent properties, and 3-thiophenylmalonic acid can be used as a fluorescent probe to detect the presence and concentration of metal ions and other molecules.
3. Dyes: As an intermediate of organic dyes, 3-thiophenemalonic acid has certain applications in the dye industry.
Method:
The synthesis of 3-thiophene malonic acid can be obtained by reacting 3-thienealdehyde with sodium thiocyanate, and then hydrolyzing the resulting hydrazone compound.
Safety Information:
1. 3-thiophenemalonic acid has low toxicity under normal conditions, but care should still be taken to avoid inhalation and contact with skin, eyes, etc.
2. When handling and storing 3-thiophenemalonic acid, attention should be paid to fire and explosion protection, and good ventilation conditions should be maintained.
3. When handling 3-thiophenemalonic acid or its related compounds, follow the safety principles of general chemical handling and waste disposal.