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4-AMino-5-Methylpyridin-2-ol(CAS NO.:95306-64-2)

4-Amino-5-methyl-2-hydroxypyridine is a key intermediate in the synthesis of finerenone, a non-steroidal selective mineralocorticoid receptor antagonist, which can be prepared from 2-chloro-4-amino-5-methylpyridine, and is also a very important organic ligand.

    Basic information

    Product Name: 4-AMino-5-Methylpyridin-2-ol
    Synonyms: 
    CAS: 95306-64-2
    MF: C6H8N2O
    MW: 124.14

    Chemical Properties

    Boiling Point: 291.0±33.0℃ (760 Torr)
    Density: 1.137±0.06 g/cm3 (20 ºC 760 Torr)
    storage temp: 2-8°C(protect from light)
    Solubility: NA
    Form: NA
    Pka: 11.90±0.10(Predicted)
    Color: NA
    InChI: InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)
    InChIKey: SSQZBQXJYGNUSC-UHFFFAOYSA-N
    SMILES: C1(=O)NC=C(C)C(N)=C1

    product description

    Quality:
    - Appearance: White crystalline solid
    - Solubility: High solubility in water and organic solvents
    - It is a compound that is alkaline
    - May react with oxygen combustion
    Use:
    4-Amino-5-methylpyridine-2-ol can be used as an intermediate in the synthesis of other compounds in industry.
    Method:
    The preparation method of 4-amino-5-methylpyridine-2-ol can be achieved by the following steps:
    The methyl chain is reacted with pyridine or pyridine derivatives to form a 4-methylpyridine compound.
    4-methylpyridine reacts with chloroethanol to form the 4-chloro-5-methylpyridine compound.
    3. 4-chloro-5-methylpyridine is heated in ammonia water to replace the amino group with chlorine atoms to form the final product 4-amino-5-methylpyridine-2-ol.
    Safety Information:
    - When using or handling this compound, appropriate personal protective equipment such as lab gloves, safety glasses, and protective clothing should be worn.
    - Avoid inhalation or contact with the compound and avoid contact with eyes, skin and mucous membranes.
    - Maintain good ventilation during operation.
    - Store in an airtight container away from contact with oxygen or other oxidizing agents.
    When using this compound in practice, it is important to consult more detailed references and follow safe operating procedures.

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