Ilaprazole(CAS NO.:172152-36-2)
Basic information
Product Name: Ilaprazole
Synonyms:
CAS: 172152-36-2
MF: C19H18N4O2S
MW:366.44
Chemical Properties
Boiling point: 651.0±65.0 °C(Predicted)
Density: 1.39
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility DMF: 10mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:7): 0.12mg/mL; Ethanol: 0.3mg/mL
Form: A solid
Pka: 8.23±0.10(Predicted)
Color: Off-white to gray
InChI: InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)
InChIKey: HRRXCXABAPSOCP-UHFFFAOYSA-N
SMILES: C1(S(CC2=NC=CC(OC)=C2C)=O)NC2=CC(N3C=CC=C3)=CC=C2N=1
Product Introduction
Ilaprazole is a potent proton pump inhibitor (PPI) with the following characteristics and information:
Pharmacological Action
Potent Inhibition: Ilaprazole is a potent proton pump inhibitor, with the strongest effect on gastric acid inhibition among similar drugs.
Irreversible Type: It belongs to the irreversible proton pump inhibitors, meaning that once it binds to H+/K+-ATPase, the inhibitory effect is long-lasting.
Benzimidazole Class: Its structure belongs to the benzimidazole class, which is a commonly used class of proton pump inhibitors.
Selective Action: Ilaprazole selectively enters the gastric parietal cells after oral administration and is converted into a sulfonamide active metabolite.
Covalent Binding: It acts with the thiol group on H+/K+-ATPase, forming a disulfide bond covalent binding, which irreversibly inhibits H+/K+-ATPase.
Uses
Treatment of Diseases: Mainly used for the treatment of gastric erosion, gastritis, reflux esophagitis, peptic ulcers, and infections such as Helicobacter pylori.
Inhibition of H+/K+-ATPase: Ilaprazole can inhibit H+/K+-ATPase, with an IC50 of 6μM, indicating its high inhibitory potency.
Side Effects
Common Side Effects: Include diarrhea (2.41%), dizziness (2.41%), and increased blood cell transaminases (ALT/AST) (1.81%).
Rare Side Effects: Rash, urticaria, lower back pain, abdominal bloating, dry mouth, bitter taste, shortness of breath, chest tightness, palpitations, increased menstrual time, renal function abnormalities (proteinuria, increased BUN), electrocardiogram abnormalities (ventricular premature contractions, first-degree atrioventricular block), leukopenia, etc.
Characteristics of Side Effects: The side effects mentioned are usually mild to moderate and can be self-healing in most cases.
Ilaprazole, as an effective inhibitor of gastric acid secretion, plays an important role in the treatment of diseases related to excessive gastric acid. However, like all medications, it is important to pay attention to its potential side effects and use it reasonably under the guidance of a physician.