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Methylene blue was first synthesized in 1876 by zinc chloride salt, and then it was mainly used for: (1) methemoglobinemia: low concentration methylene blue is used for the treatment of methemoglobinemia caused by nitrite, chlorate, quinones, quinonesimines, aniline and nitrobenzene; (2) Cyanide poisoning: high concentration of methylene blue can be used for cyanide poisoning; (3) Combined with local Chemicalbook anesthetic for local analgesia; (4) In recent years, it has also been clinically used to treat infectious and traumatic shock, cancer, herpes zoster, etc. Pharmacological studies have shown that methylene blue has detoxification, analgesic, antibacterial, antiviral, antitumor effects, and can correct hemodynamic disorders in patients with septic shock, and treat priapism.