pyridine-3-sulfonyl chloride(CAS NO.:16133-25-8 Vonoprazan intermediate)
Basic information
Product Name: pyridine-3-sulfonyl chloride
Synonyms:
CAS: 16133-25-8
MF: C5H4ClNO2S
MW: 177.61
Chemical Properties
Boiling Point: 284℃
Density: 1.488
storage temp: under inert gas (nitrogen or Argon) at 2-8°C
Solubility: Chloroform (Sparingly), Methanol (Slightly)
Form: liquid
Pka: -1.77±0.11(Predicted)
Color: Colourless to light yellow
InChI: InChI=1S/C5H4ClNO2S/c6-10(8,9)5-2-1-3-7-4-5/h1-4H
InChIKey: CDRNYKLYADJTMN-UHFFFAOYSA-N
SMILES: C1=NC=CC=C1S(Cl)(=O)=O
product description
The following is an introduction to the properties, uses, preparation methods and safety information of pyridine-3-sulfonyl chloride:
Quality:
- Appearance: Pyridin-3-sulfonyl chloride is a colorless to pale yellow liquid.
- Solubility: Soluble in organic solvents such as ethers, alcohols and chlorinated hydrocarbons.
Use:
- Pyridin-3-sulfonyl chloride is a commonly used reagent in organic synthesis for the introduction of pyridine sulfonyl chloride groups, and is commonly used as an esterification, acetal, and alkylation reaction reagent for aromatic hydrocarbons and aryl boronic acids.
Method:
- Pyridine-3-sulfonyl chloride can be formed by the reaction of pyridine and thionyl chloride.
Safety Information:
- Pyridine-3-sulfonyl chloride is irritating and can cause inflammation and irritation in contact with the skin and eyes. Care should be taken to use personal protective equipment such as laboratory gloves and goggles during contact.
- It is also a flammable liquid and should be used in a well-ventilated area and away from open flames and heat sources.